晚期治疗前一天与早晨结肠镜检查的低体积PEG-CS标准分剂量:多中心随机对照试验
Luigi Pasquale1, Giuseppe Grande2, Rocco Maurizio Zagari3
1Gastroenterology Unit, Monaldi Hospital, Napoli, Italy.
Endoscopy international open
|February 26, 2025
概括
前一天的晚期 (DBL) 肠道准备效果不如一夜间分剂量 (SD) 结肠镜治疗方案. 然而,DBL在非常早晨的手术中表现出类似的疗效,并改善了患者的舒适度.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 临床试验研究 临床试验研究
背景情况:
- 夜间分割剂量 (SD) 肠道制备是早晨结肠镜检查的标准,尽管坚持存在挑战.
- 低容量制剂越来越多地用于结肠清洁.
研究的目的:
- 为了比较"早一天" (DBL) 治疗方案的疗效和耐受性,与在早上8点到10点之间安排的结肠镜检查的夜间SD治疗方案进行比较.
- 评估肠道清洗的成功,安全性,合规性和患者报告的结果.
主要方法:
- 随机对照试验涉及DBL组的162名患者和SD组的158名患者.
- DBL涉及在晚上8:30到午夜之间服用整个低容量制剂.
- SD涉及在手术前5小时服用第二剂.
- 使用波士顿肠道准备分数 (BBPS) 评估了肠道清洁.
主要成果:
- DBL疗法在整体肠道清洁方面效果不如SD疗法 (88.2%对98.1%,P<0.001).
- 在上午9点前的结肠镜检查中,BBPS≥3的发病率相似 (94.6%为DBL,100%为SD,P=0.126).
- DBL患者报告说,他们对失禁的恐惧较小 (13.9%与25.5%,P = 0.01),并且表现出类似的遵守性和耐受性.
结论:
- 对于早上8到10点的结肠镜检查,DBL疗法效果较差,但对于早上9点前的手术来说,它可能是一个可行的替代方案.
- DBL疗法为患者提供了更好的舒适度,以避免患有失禁的恐惧.
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