评估过敏性鼻炎儿童肠道微生物组的改变:与过敏原特定IgE水平和敏感化模式的关联
Junyang Li1,2, Yanan Shi1, Lanye Hu2
1Department of Otolaryngology, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, People's Republic of China.
Journal of asthma and allergy
|February 26, 2025
概括
特定的肠道细菌,特别是Streptococcus salivarius,可能表明过敏性鼻炎儿童的家尘虫敏感度水平. 这一发现可能导致过敏性鼻炎的新疗法.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 儿科过敏症儿童过敏症
背景情况:
- 肠道微生物群在过敏性鼻炎 (AR) 中的作用及其与过敏原暴露的关联,特别是家庭灰尘虫 (HDM) 敏感性,尚未完全理解.
- 肠道微生物群在不同水平的过敏原特异性IgE (sIgE) 和单敏化和多敏化之间的变化需要进一步调查.
研究的目的:
- 为了研究患有HDM诱导的AR的儿童的肠道微生物群组成.
- 为了比较不同的HDM-sIgE水平 (极高,高) 和敏感化模式 (单敏化,多敏化) 的肠道微生物群概况.
主要方法:
- 甲基因组猎枪测序被用来分析便微生物群.
- 88名患有HDM-AR的儿童与50名健康对照 (HC) 的儿童进行了比较.
- 根据HDM-sIgE水平和敏感性状态进行了子组分析.
主要成果:
- 在HC和HDM-AR组之间,整体肠道微生物群多样性没有显著差异.
- 在患有AR的儿童中增加了*Streptococcus sanguinis*的相对丰度.
- 在患有极高HDM-sIgE的儿童中,丰富了*Streptococcus*属,特别是*Streptococcus salivarius*.
- 与HC和多重敏感 (多重HDM) 组相比,单重敏感 (单重HDM) 组的*Streptococcus salivarius*显著增加.
- 功能分析表明液分泌途径中的丰富.
结论:
- *Streptococcus salivarius*可能作为评估HDM敏感性严重程度和模式的潜在生物标志物.
- 这些发现表明有针对性的干预措施来管理AR病理生理学的潜力.
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