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腹腔大动脉动脉瘤的液体结构相互作用分析:多层组织结构和内血栓的作用

Xinhai Yue¹, Jiayi Huang¹, Ju Liu¹

¹Department of Mechanics and Aerospace Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Frontiers in bioengineering and biotechnology

|February 26, 2025

概括

生物力学分析显示,多层大动脉壁和内血栓 (ILT) 显著影响腹腔大动脉瘤 (AAA) 破裂风险. 纳入这些因素可以改善预测AAA断裂的生物力学评估.

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
计算力学计算力学计算力学

背景情况:

腹腔大动脉动脉瘤 (AAA) 是一种危险的疾病,其特征是大动脉壁扩张.
目前的临床指南依赖于动脉瘤直径,这可能无法准确预测破裂风险.
需要先进的生物力学分析来改善AAA破裂风险评估.

研究的目的:

研究多层大动脉组织和内血栓 (ILT) 对AAA壁应力分布的影响.
在各种条件下分析不同AAA形态 (形和形) 的生物力学反应.
评估组织降解对AAA生物力学的影响.

主要方法:

使用流体结构相互作用 (FSI) 建模来模拟AAA生物力学.
分析包括具有和没有ILT的模型,以及不同程度的组织降解.
进行了单层和多层组织模型之间的比较.

主要成果:

介质层在AAA.中被确定为主要承载层.
与单层模型相比,多层组织模型提供了更准确的应力概况.
ILT显著降低了整体壁面应力,尽管它对峰值应力位置的影响有所不同.
媒介退化增加了其他层的压力,但ILT在很大程度上减轻了这种影响.

结论:

多层组织架构和ILT是患者特异性AAA生物力学分析的关键因素.
纳入这些元素可以提高对AAA破裂风险的生物力学评估的预测准确性.
这些发现支持对AAA患者进行更精细的风险分层.

关键词:

腹部大动脉动脉瘤腹部大动脉动脉瘤流体结构相互作用.内血栓是指内血栓.多层异性质组织模型针对患者的特定建模.

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