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延迟喘诊断与儿童喘恶化之间的关联
Chung-Il Wi1,2, Euijung Ryu2,3, Katherine S King2,4
1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn.
The journal of allergy and clinical immunology. Global
|February 26, 2025
概括
儿童喘的延迟诊断增加了喘恶化 (AE) 的风险. 及时诊断 (TD) 对于管理儿科喘和预防AEs至关重要.
科学领域:
- 儿科肺病学 儿科肺病学
- 临床流行病学临床流行病学
- 健康 结果 研究 研究 结果
背景情况:
- 在儿童喘的症状发作和诊断之间存在显著的时间滞后.
- 这种诊断延迟对儿科喘结果的临床影响仍然不完全理解.
研究的目的:
- 调查喘延迟诊断与儿童喘恶化发生之间的关联.
- 为了比较晚诊儿童和及时诊断儿童之间的喘恶化风险.
主要方法:
- 利用了梅奥诊所的出生队列数据和电子健康记录.
- 延迟诊断 (DD) 定义为诊断>30天从症状发作,与及时诊断 (TD) 在30天内形成对比.
- 采用考克斯的比例危险模型来评估喘恶化风险,调整共变量.
主要成果:
- 在537个匹配对中,DD儿童的喘恶化风险显著增加 (调整后的危险比:1.53;P<.001).
- 随访时间中位数为9.3年,DD组的344名儿童和TD组的253名儿童至少经历了一次恶化.
结论:
- 儿童喘的延迟诊断与喘恶化风险更高有关.
- 优先考虑及时诊断对于有效的儿童喘管理和改善患者结果至关重要.
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