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Updated: May 25, 2025

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In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
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由瘤相关的巨细胞调节瘤微环境:对乳腺癌中新辅助化疗反应的影响
Gizem Oner1,2,3, Marleen Marguerite Praet4, Hans Stoop4
1Multidisciplinary Oncologic Centre Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium.
Breast cancer (Dove Medical Press)
|February 26, 2025
概括
在乳腺癌 (BC) 中的新辅助化疗 (NAC) 后,与瘤相关的巨细胞 (TAM) 显著减少. 持久的CD163+TAM与较大的残留瘤相关,这表明它们在化疗耐药性和潜在的治疗点中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 瘤相关巨细胞 (TAMs) 是乳腺癌 (BC) 瘤微环境的关键组成部分,影响瘤进展.
- 针对BC新辅助化疗 (NAC) 的反应中TAM亚型的特定作用仍然不完全理解.
研究的目的:
- 研究乳腺癌中NAC期间TAM亚型 (CD68+和CD163+) 的动态.
- 评估TAM水平与治疗反应之间的关联,包括剩余瘤大小和剩余癌症负担指数 (RCB).
主要方法:
- 免疫组织化学 (IHC) 用于量化138名BC患者在NAC前后的瘤组织中的CD68+和CD163+TAM.
- 通过瘤大小和RCB指数的变化来评估NAC反应.
主要成果:
- 在NAC后的肌瘤和瘤巢中观察到CD68+和CD163+TAM的显著减少.
- 侧膜中CD68+和CD163+TAM的较高NAC后水平与较大的残留瘤大小有很强的相关性.
- 在NAC后的CD163+TAM水平与RCB类显著相关.
结论:
- 在塑造乳腺癌中对NAC的反应方面,TAM动态起着至关重要的作用.
- CD163+ TAMs与化疗耐药性机制有关,并代表BC的潜在生物标志物和治疗点.
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