后COVID状态中的结构性大脑变化及其与认知障碍的关系
Laura Pacheco-Jaime1,2, Carla Garcia-Vicente1,2, Mar Ariza1,3
1Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Catalonia, Spain.
Brain communications
|February 26, 2025
概括
后COVID状态与长期的大脑变化有关,包括皮质厚度和白质完整性的改变,这与记忆和处理速度障碍等认知缺陷相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID状态影响了SARS-CoV-2感染个体的很大比例.
- 认知功能障碍和结构性大脑变化在COVID后的状态中被注意到,但它们之间的关系仍然不清楚.
- 长期COVID-19的神经系统后果需要进一步调查.
研究的目的:
- 为了研究后COVID状态患者的结构性大脑变化,感染后近两年.
- 探索这些大脑变化与认知障碍之间的关系.
- 检查与血液生物标志物和临床变量之间的关联.
主要方法:
- 结构性脑磁共振成像 (MRI) 和全面的神经心理评估对128名后COVID患者和37名对照进行.
- 分析了皮层厚度,皮层下体积,灰质分析和白质完整性 (扩散张力成像).
- 在一小部分参与者中评估了血液生物标志物水平.
主要成果:
- 与对照人群相比,后COVID患者在工作记忆,口头记忆,处理速度,口头流和执行功能方面表现出显著的缺陷.
- 在特定的额头区域皮质厚度的增加与工作记忆性能有负相关性.
- 在关键路径中减少白质完整性 (微分异型性),与主观记忆失败相关. 没有发现血液生物标志物的显著差异.
结论:
- 在COVID后的患者中,灰色和白质结构的改变在感染后的两年内仍然存在.
- 这些大脑变化部分解释了在这个人群中观察到的长期认知缺陷.
- 监测COVID后病情的个体对于理解和管理长期神经效应至关重要.
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