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Updated: May 25, 2025

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IL-23调整人体粘膜关联不变T细胞的炎症功能

Laetitia Camard1, Tharshana Stephen1,2, Hanane Yahia-Cherbal1

  • 1Immunoregulation Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, 75015 Paris, France.

iScience
|February 26, 2025
PubMed
概括

粘膜关联不变T细胞 (MAIT) 是介质素-23 (IL-23) 信号的关键标,影响慢性炎症和传染病. 这项研究揭示了MAIT细胞的可塑性,并确定AP-1转录因子是IL-23反应的关键调节者.

关键词:
免疫学 免疫学 免疫学文字转录学 (Transcriptomics) 是一个学科.

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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