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巴厘岛的登革热动态:过去10年的血清型转移,基因型替代和多种病毒血统循环

R Tedjo Sasmono¹, Sri Masyeni², Rahma F Hayati³

¹Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Cibinong, Bogor, Indonesia.

Tropical medicine & international health : TM & IH

|February 26, 2025

概括

在过去的十年里,巴厘岛的登革热病毒 (DENV) 血清型的占主导地位发生了变化,DENV-1被DENV-3取代. 持续监测对于预测未来登革热疫情在这个高度流行地区至关重要.

科学领域:

医学昆虫学医学昆虫学
病毒学病毒学
流行病学流行病学

背景情况:

巴厘岛经常发生登革热病毒 (DENV) 爆发,这给公共卫生带来了重大挑战.
尽管发病率很高,但缺乏全面和持续的DENV监测.
这项研究旨在通过血清型和基因型监测来监测DENV传播动态.

研究的目的:

在巴厘岛进行DENV血清型和基因型监测.
监测病毒传播动态,了解流行病学转变.
为改善登革热爆发预测和控制提供数据.

主要方法:

患有登革热症状的发烧患者被招收到巴厘岛丹帕萨尔的医院.
使用RT-PCR识别了DENV血清型,并通过测序进行基因定型.
用近期和回顾性序列数据进行了家族遗传分析.

主要成果:

DENV血清型的流行率从DENV-1 (2018-2020年) 转移到了DENV-3 (2022年).
观察到基因型更换,DENV-1基因型IV被基因型I取代.
多个DENV血统流传,Cosmopolitan,基因型I和基因型II分别为DENV-2,DENV-3和DENV-4占主导地位.

结论:

巴厘岛的DENV血清型的占主导地位在过去10年中发生了转变.
遗传多样性和循环DENV的动态性质有助于每年爆发疫情.
常规监测对于了解DENV血清型模式和预测未来疫情至关重要.

关键词:

巴利巴利巴利巴利巴利登革热:登革热是指登革热的一种疾病.基因型基因型基因型人类的基因组学.血清型的血清型是什么

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