密码性中风患者恶性查工具:系统性审查
Maria P Tieck1,2, Constanze Single1, Sven Poli1,2
1Department of Neurology & Stroke, University Hospital Tübingen, Tübingen, Germany.
European stroke journal
|February 26, 2025
概括
高达20%的密码性缺血性中风患者有隐藏的癌症,这为早期检测提供了机会. 本综述建议使用D-二次体水平和中风模式来指导这些患者的癌症查.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 诊断医学 诊断医学
背景情况:
- 密码性缺血性中风 (CIS) 在多达20%的病例中与隐性恶性瘤有关.
- 在中风评估期间早期发现癌症是一个关键的临床机会.
- 目前的国际指导方针在CIS患者的系统恶性查方面缺乏共识.
研究的目的:
- 审查临床特征,分数和实验室测试的现有证据,以指导CIS患者恶性查.
- 提出一种决策流程图,用于在缺血性中风中对恶性瘤进行查.
- 突出临床影响和需要基于证据的指导方针,用于癌症查在CIS.
主要方法:
- 在PubMed,MEDLINE和Cochrane数据库中的系统文献搜索.
- 包括12项符合预先定义的审查标准的研究.
- 分析临床特征,预测得分和用于恶性瘤检测的实验室测试.
主要成果:
- 在不同大脑循环中增加的D-二次体水平和多次心脏病发作是隐性恶性瘤的关键标志物.
- 建议在脑成像上使用D-二次元切断和中风模式的风险分层方法.
- 推的诊断工作准了流行癌症,如胃肠道,肺腺癌和与性别相关的癌症.
结论:
- 在密码性缺血性中风患者的恶性查可以导致早期癌症诊断.
- 使用D-二次体水平和神经成像发现的结构化方法可以指导诊断工作.
- 迫切需要基于证据的指导方针,以在这种患者群体中标准化恶性查.
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