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来自ISMRM扩散研究小组对临床前扩散MRI的考虑和建议:第1部分:体内小动物成像:体内小动物成像

Ileana O Jelescu^1,2, Francesco Grussu^3,4, Andrada Ianus^5,6

¹Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Magnetic resonance in medicine

|February 26, 2025

概括

这项研究为小型动物扩散MRI (dMRI) 提供了最佳实践建议,以提高实验严谨性和可重复性. 它涵盖实验设计,体内采集协议,以及用于临床前dMRI研究的数据处理.

科学领域:

生物医学成像技术生物医学成像技术
神经科学是一个神经科学.
比较解剖学的比较解剖学

背景情况:

小动物扩散MRI (dMRI) 对于方法论的发展,生物特征和比较解剖学至关重要.
临床前的dMRI涉及从设置到解释的复杂步骤,影响研究结果.
缺乏标准化的最佳实践,阻碍了小动物dMRI研究的严谨性和可重复性.

研究的目的:

提出关于临床前体内小动物dMRI最佳实践的专家建议.
引导研究人员进行实验设计,获取和数据处理,以提高可复制性.
通过为公开可用的数据集和软件提供资源,促进负责任的研究.

主要方法:

对社区获得的临床前dMRI最佳实践的审查和综合.
对实验设计的物种和疾病模型考虑的讨论.
关于体内采集协议 (硬件,制备,序列) 和数据处理 (预处理,模型装配,曲谱) 的建议.

主要成果:

设计和进行小动物dMRI实验的详细考虑和建议.
关于选择合适的动物模型和优化成像参数的指导.
确定缺乏指导方针的领域,突出未来的研究方向.

结论:

遵守推的最佳实践将提高小动物dMRI的严谨性和可重复性.
标准化的协议和可访问的资源对于使用临床前dMRI推进生物医学知识至关重要.
这项工作是该领域研究人员的基本指南,促进了一致和可靠的发现.

关键词:

收购收购收购收购最佳实践的最佳实践是什么扩散磁力共振成像 (MRI) 扩散扩散张力器的扩散张力器微观结构的微观结构开放科学是一个开放的科学.在临床前的临床前.处理处理处理处理小动物动物小动物动物路径学路径学路径学路径学路径学

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