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Updated: May 25, 2025

Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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针对装饰OMV货物蛋白的甘氨酸纹理具有特异性的抗体

Hyun Young Kim1,2, Christina M Rothenberger1,3, Mary E Davey1

  • 1Department of Microbiology, ADA Forsyth Institute, Cambridge, Massachusetts, USA.

mSphere
|February 26, 2025
PubMed
概括

免疫球蛋白M (IgM) 抗体特别针对来自Porphyromonas gingivalis.外膜囊泡 (OMV) 上的O-糖化蛋白. 这一发现揭示了潜在的宿主逃避策略,并建议O-甘氨酸作为P. gingivalis疫苗和治疗的目标.

关键词:
它们是IgM抗体.这是一种O-糖基化.这是一个 OMV 系统.在P. gingivalis中发现了在PG1881中使用.

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