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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

168
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
168
Sublimation01:03

Sublimation

696
Sublimation is the direct transformation of a solid to a gaseous state. For instance, at standard pressure and room temperature, solid carbon dioxide sublimes to gaseous carbon dioxide. The phase diagram depicts the conditions required for sublimation. This process occurs at the solid-gas phase boundary and is not observed above the triple point of the substance. The reverse of sublimation is called deposition, where a gaseous substance condenses directly into a solid. Sublimation and...
696
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

113
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
113
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

276
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
276
Recrystallization: Solid–Solution Equilibria01:10

Recrystallization: Solid–Solution Equilibria

1.0K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
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关于冷化的小评论:配方开发和稳定性修饰剂的基本要求

Sachin Joshi1, Priya Jindal1, Shreastha Gautam1

  • 1Department of Pharmaceutical Quality Assurance, ISF College of Pharmacy, Moga, India.

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概括

冷干燥或冷化是制造稳定的制药配方的重要过程. 这种技术增强了药物的稳定性,有效性和在各种剂量形式的输送.

关键词:
药物输送是药物输送的过程.冰干燥的使用方法溶解化 溶解化是一种稳定的稳定性 稳定的稳定性潜质化 潜质化是一种

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科学领域:

  • 制药科学 制药科学
  • 化学工程是化学工程的重要组成部分.
  • 材料科学 材料科学 材料科学

背景情况:

  • 冷干燥 (软化) 是制药配方的广泛采用的技术,特别是复杂的活性成分和药物输送系统.
  • 它涉及通过升华去除水分,这对于湿度敏感,可热或可降解的治疗化合物至关重要.
  • 诸如稳定剂,缓冲剂和填充剂之类的辅助剂往往对于保持产品外观和长期稳定性至关重要.

研究的目的:

  • 提供对冷化过程的全面概述.
  • 讨论冷凍化藥物組成中的原理,輔助劑和新興技術.
  • 突出化在各种科学和制药领域的应用.

主要方法:

  • 这篇文章回顾了冷化的基本原理,包括冷,初级干燥 (升华) 和二次干燥 (溶解).
  • 它检查了特定辅助剂在制备冷解产品中的作用.
  • 讨论包括对新型冷化技术及其应用的概述.

主要成果:

  • 软化剂对各种剂型 (口服,吸入,亲肠道) 有效,提高了治疗疗效和输送.
  • 该过程对于提高难溶性药物的可溶性和生物利用性至关重要.
  • 它有助于保存生物样本和稳定药理学研究中的参考标准.

结论:

  • 在整个开发和生命周期管理过程中,冷化对于确保药品的稳定性,有效性和安全性至关重要.
  • 这种技术为药物输送系统和敏感化合物的配方提供了显著的优势.
  • 解冷技术的进步继续扩大其在制药研究和产品开发中的实用性.