通过了解包容性临床试验的障碍和驱动因素来促进多样性
Annick de Bruin1, Jasmine Masullo1, Shalome Sine2
1The Center for Information and Study on Clinical Research Participation, Boston, MA, USA.
临床试验的多样性对于公平的医疗保健至关重要. 这项全球调查确定了代表性不足的种族群体面临的独特障碍,强调需要包容性试验设计,以改善参与和结果.
科学领域:
- 临床试验的多样性和包容性
- 卫生公平研究 卫生公平研究
- 以患者为中心的试验设计.
背景情况:
- 临床试验中的公平代表对于药物开发和医疗保健结果至关重要.
- 了解包容性试验的障碍和驱动因素至关重要,特别是在代表性不足的人群中.
研究的目的:
- 调查影响不同种族和族群参与临床试验的态度,感知,经验和挑战.
- 确定跨越不同族群的临床研究准入和参与的具体障碍.
主要方法:
- 一项全球在线调查于2023年4月至6月进行,来自54个国家的12,017名受访者参与了调查.
- 参与者是通过患者组织和倡导团体招募的,成年人18+有在线访问的资格.
- 统计分析比较了种族和种族群体对与临床试验相关的看法,担忧和经验的反应.
主要成果:
- 参与临床试验的障碍因种族而异.
- 亚洲受访者更关心工作时间和时间承诺;西班牙裔受访者更关心工作休息时间和接受安慰剂.
- 黑人和西班牙裔受访者优先考虑员工多样性,而不是白人受访者,黑人,亚裔和西班牙裔受访者报告说,技术和家庭学习要求造成的干扰更大.
结论:
- 这些发现强调了在临床试验中解决多样性障碍的必要性.
- 改善代表性不足的社区的试验经验是设计更具包容性和以患者为中心的研究的关键.
- 需要量身定制的战略来克服特定种族的挑战,并促进公平参与临床研究.
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