黑素的使用对低雌激素的动物的骨特性:一个系统的审查
Taciane Maria Melges Pejon1, Leonardo Henrique Dalcheco Messias2, Rafael Henrique de Oliveira Nascimento1
1Laboratory of Endocrine Physiology and Physical Exercise, Department of Physiological Sciences, Federal University of São Carlos, Washington Luis, Km 235, São Carlos, São Paulo, 13565-905, Brazil.
Reviews in endocrine & metabolic disorders
|February 26, 2025
概括
补充黑色素可以改善动物模型的骨密度和强度,具有低雌激素. 这项研究强调了黑激素.
科学领域:
- 骨生物学和新陈代谢
- 内分泌学和荷尔蒙调节
- 药理学和治疗学 药理学和治疗学
背景情况:
- 低雌激素导致显著的骨损失,增加骨折风险.
- 黑激素是一种具有已知的骨作用性质的激素,正在作为一种潜在的治疗剂进行探索.
- 了解黑激素在低雌激素状态下的作用对于开发骨保存策略至关重要.
研究的目的:
- 系统地审查慢性黑激素给药对经历低雌激素的动物模型骨组织的影响.
- 巩固有关黑激素对骨密度,强度和分子标记物的影响的证据.
主要方法:
- 在PubMed,Web of Science和Scopus数据库中进行了系统的文献搜索.
- 包括以英语编写的受控动物研究,发表时间至2023年11月.
- 数据提取的重点是动物的特征,黑激素的管理细节,以及骨性质的结果.
主要成果:
- 在19项研究中,黑素的使用改善了骨矿物质密度,骨体积和状骨数.
- 在7项研究中观察到增强的生物力学特性,包括最大负载和刚性.
- 黑素调节关键骨相关基因表达 (RUNX2,OCN,OPG,RANKL) 并增加了血清骨素水平.
结论:
- 长期服用黑激素对骨的生物物理,生物机械,分子和生物化学性质产生有益影响.
- 黑色素促进骨质生效,这表明它在低雌激素主义期间保护骨微观结构和质量的有效性.
- 黑色素代表了一种有前途的治疗策略,用于管理与低雌激素条件相关的骨损失.
相关概念视频
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Management of Insomnia
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...


