一种与瘤结合的抗体,对病毒抗原具有交叉反应性
Michael J Campa1, Elizabeth B Gottlin1, Kevin Wiehe2,3
1Department of Radiology, Duke University School of Medicine, Durham, NC, 27710, USA.
Cancer immunology, immunotherapy : CII
|February 26, 2025
概括
在非小细胞肺癌 (NSCLC) 中,向补充因子H (CFH) 的自身抗体可能源于先前的病毒感染. 这表明病毒免疫和抗瘤反应之间存在潜在的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 在非小细胞肺癌 (NSCLC) 患者中发现了补充H因子 (CFH) 的自身抗体,与有利的疾病特征有关.
- 来自这些患者的重组抗体GT103通过抑制瘤生长和调节瘤微环境,显示出抗瘤特性.
- 自体抗体和GT103都识别了CFH的SCR19域内的特定表位体 (PIDNGDIT).
研究的目的:
- 为了调查在NSCLC患者中发现的抗CFH自身抗体的潜在病毒源.
- 为了探索以前的病毒感染是否可以引起一种幽默性免疫反应,针对瘤细胞上类似的表位.
主要方法:
- 鉴定和合成具有与核心PIDNGDIT表型高度序列相同的同类病毒.
- 使用NSCLC患者血进行ELISA测定,以检测针对合成的病毒的抗CFH自身抗体.
- 在病原体微阵列上对GT103的检测,以确定交叉反应性病毒表位.
主要成果:
- 在几种病毒中发现了与GT103表位同源的表位,包括人类甲肺病毒-1 (HMPV-1).
- 患有NSCLC的患者血对含有表位组的HMPV-1具有较弱的结合.
- GT103与多种病毒表位基因交叉反应,特别是来自人类内源性逆转录病毒-K聚合酶 (HERV-K pol) 和麻疹血凝蛋白糖蛋白,尽管相对于CFH表位基因的亲和力较低.
结论:
- 这些发现表明,最初响应病毒标的记忆B细胞可能会经历亲和力成熟.
- 这一过程可能导致产生抗体,识别瘤细胞上类似的表位.
- 这些抗体可能具有抗瘤特性,在NSCLC中提供潜在的治疗途径.
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