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相关概念视频

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

462
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
462
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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相关实验视频

Updated: May 25, 2025

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
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Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

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对于CSCC来说,不断变化的治疗环境.

David M Miller1,2,3

  • 1Department of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital, Boston, USA. dmiller4@mgh.harvard.edu.

Archives of dermatological research
|February 26, 2025
PubMed
概括
此摘要是机器生成的。

免疫疗法正在彻底改变皮肤状细胞癌 (CSCC) 治疗方法,为皮肤科医生提供了新的选择. 免疫检查点抑制剂 (ICI) 在晚期CSCC和潜在的高风险局部疾病中表现有前途.

关键词:
皮肤状细胞癌瘤免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.

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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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相关实验视频

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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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科学领域:

  • 皮肤病学 皮肤病学
  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学

背景情况:

  • 皮肤状细胞癌 (CSCC) 的管理正在发展.
  • 免疫疗法正在改变CSCC在所有疾病阶段的护理.
  • 手术和放射治疗是局部CSCC的标准,但晚期疾病需要全身选择.

研究的目的:

  • 审查CSCC不断变化的治疗环境.
  • 突出免疫疗法的作用,包括免疫检查点抑制剂 (ICI),在CSCC管理中.
  • 讨论ICI在皮肤病学中的新兴应用.

主要方法:

  • 关于CSCC治疗的当前文献的综述.
  • 免疫治疗对CSCC的影响分析.
  • 讨论新辅助剂,辅助剂和内部损伤性ICI策略.
  • 探索抗PD-1治疗行为性瘤综合征的方法.

主要成果:

  • 免疫检查点抑制剂 (ICI) 在先进的CSCC中提供持久的反应和生存益处.
  • 新兴的ICI策略 (新辅助剂,辅助剂,内伤) 可能会改善高风险,可切除的CSCC的结果.
  • 抗PD-1疗法显示出预防行动性瘤综合征的潜力,需要进一步调查.

结论:

  • 免疫疗法正在扩大皮肤科医生在CSCC管理中的作用.
  • 皮肤科医生必须准备好通过合作和培训来管理与免疫治疗相关的不良事件.
  • 持续的研究和对免疫疗法的深思熟虑的应用对于优化CSCC护理至关重要.