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在非常早产新生儿中对抗微生物耐药生物的流行研究
Elaine Houlihan1, Anna McCormick2, Carol O ' Connor2
1Department of Clinical Microbiology, National Maternity Hospital, Holles Street, Dublin, D02YH21, Ireland. e.houlihan.kenny@gmail.com.
Irish journal of medical science
|February 26, 2025
概括
在NICU中非常早产的婴儿经常携带抗生素耐药的生物体,特别是AMPC生产者. 这凸显了在新生儿重症监护机构加强感染控制和对多药物耐药生物体的查的需要.
科学领域:
- 新生儿重症监护中心
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 过早出生的新生儿 (妊娠32周以下) 容易受到感染,原因是器官系统,皮肤屏障和免疫功能不成熟.
- 由于抗生素暴露和侵入性监测等因素,在NICU设置中,医疗保健相关感染 (HAI) 的风险较高.
- 这项研究旨在确定在非常早产新生儿中抗菌素耐药性生物体携带的流行率.
研究的目的:
- 调查进入新生儿重症监护室 (NICU) 的非常早产新生儿中抗微生物耐药性生物携带的流行情况.
- 为了确定特定类型的耐药生物殖民这个脆弱的人口.
- 在新生儿重症监护中为感染预防和控制策略提供信息.
主要方法:
- 从2022年9月到2023年1月,一组孕期≤32周出生的新生儿进行了查.
- 抽样是在入院时收集的,并且每两周一次,直到生命的第10周.
- 查包括扩展光谱β-乳酸酶 (ESBL),AmpC生产者,抗 gentamicin/ciprofloxacin,产生卡巴酶的肠杆菌 (CPE),抗甲素的金黄色葡萄球菌 (MRSA) 和抗香素的肠杆菌 (VRE).
主要成果:
- 38% (20/53) 的新生儿至少携带了一种耐药性格拉姆阴性生物.
- 流行率包括9%的ESBL,4%的 gentamicin 耐药性,11%的 ciprofloxacin 耐药性和26%的 AmpC 生产者.
- 抵抗率在第4周达到顶峰;没有检测到CPE,MRSA或VRE.
结论:
- 在NICU中,很大一部分非常早产的婴儿携带了抗生素耐药的生物.
- 调查结果强调了强有力的感染预防,控制和抗微生物药物管理的重要性.
- 在新生儿重症监护机构建议定期对多药耐药生物体 (MDROs) 进行查.
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