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种族差异在ctDNA档案,向治疗的使用,以及转移性乳腺癌的结果

Emily L Podany¹, Lorenzo Foffano², Lorenzo Gerratana²

¹Department of Medicine, Washington University in St Louis, St Louis, Missouri.

JAMA network open

|February 26, 2025

概括

与白人患者相比,黑人患有转移性乳腺癌的患者具有不同的基因组配置文件,并且在PI3K抑制剂使用方面存在差异,这导致了更差的生存结果. 需要进一步的研究来解决这些不平等问题.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
健康差异在健康上的差异

背景情况:

黑人患有转移性乳腺癌 (mBC) 的患者的死亡率高于白人患者.
治疗的进步并没有完全消除这种生存差距.

研究的目的:

为了研究黑人和白人患有mBC的患者之间的基因组特征差异.
评估这些患者群体之间使用向疗法的不平等情况,包括PI3K,mTOR和CDK4/6抑制剂.

主要方法:

对经过基因组分析的mBC成年患者进行回顾性,基于人口的队列研究.
分析循环瘤DNA (ctDNA) 档案和针对性治疗的使用.
在大量基于人口的队列中验证.

主要成果:

黑人患者的GATA3和CCND2变异的发生率显著更高.
尽管PIK3CA变异频率相似,但黑人患者接受PI3K抑制剂的可能性较低.
黑人患者在CTDNA测试后的整体存活期较短.

结论:

黑人和白人的mBC患者之间存在基因组差异和PI3K抑制剂使用的差异.
这些因素导致黑人患者的生存结果较差.
未来的研究和干预必须解决这些不平等问题,以缩小成果差距.

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