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在抗性上皮卵巢卵巢癌中,Olaparib和Palbociclib的协同作用

Shuo Wang1, Yan Gao1

  • 1Department of gynecology surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology，N44 Xiaoheyan Road, Dadong distric, Shenyang 110042, Liaoning, People's Republic of China.

American journal of physiology. Cell physiology
|February 26, 2025
PubMed
概括

这项研究表明,将多ADP-ribose聚合酶抑制剂 (PARPi) 与循环素依赖性激酶4/6抑制剂 (CDK4/6i) 结合起来,可以有效地减少耐药性上皮卵巢癌 (EOC) 的瘤生长. 这种组合疗法为克服PARPi耐药性的治疗提供了一个有希望的策略.

关键词:
综合治疗 综合治疗循环素依赖性基因酶 4/6 抑制剂卵巢上皮癌 卵巢上皮癌阻力机制 阻力机制

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