协调在放射性药物治疗后释放患者的实践
Larisa Chipiga1,2,3, Anastasia Likhacheva1,4, Aleksandr Vodovatov1,5
1Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Saint-Petersburg, Russia.
制定放射性药物治疗 (RPT) 患者释放标准至关重要. 一种推的方法考虑了放射性核素衰变和1mSv的公共剂量限制,确保患者运输和废物管理期间对公众的辐射安全.
科学领域:
- 核医学是一种核医学.
- 放射性药物疗法是一种放射性药物疗法.
- 辐射安全 辐射安全
背景情况:
- 放射性药物治疗 (RPT) 的实施面临着辐射安全方面的挑战,特别是关于患者和放射性废物对公众的暴露.
- 协调患者释放标准对于新型治疗放射性药物至关重要.
研究的目的:
- 为了比较不同患者释放标准,RPT的方法.
- 评估患者运输和生物废物管理期间公众的辐射暴露.
- 为了评估特定放射性药物的标准: 177Lu-PSMA-617,177Lu-DOTATATE,131I,131I-mIBG,以及153Sm-oxabifor. 这些标准包括:
主要方法:
- 分析了患者释放标准的两个主要方法:一种仅基于放射性衰变,另一种包含放射性衰变和生物消除 (有效半衰期).
- 对于第二种方法,考虑了每疗程1 mSv和5 mSv的剂量限制.
- 在RPT后的各种患者旅行场景下,估计了公共交通乘客和工作人员的有效剂量率.
主要成果:
- 患者运输期间的公共辐射安全必须考虑在释放标准的制定中.
- 建议采用基于放射性核素衰变的方法,并对与公众接触的1mSv剂量限制.
- 建议在服用药物后将患者住院4-6小时.
结论:
- 推的患者释放标准方法确保了公共辐射安全,并符合国际标准.
- 协调的标准有助于新型RPT剂的安全实施.
- 有效管理患者释放和废物是RPT安全的关键.
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