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长期控制释放,减少初始突发释放,使用离子触发的纳米聚合物,用于加载化的贫化素纳米颗粒
Eun Jin Baek1, Hy Dinh Nguyen1, Hai Van Ngo1
1Department of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
International journal of pharmaceutics
|February 26, 2025
概括
这项研究开发了带有的专纳米颗粒,可以随着时间的推移控制药物释放. 离子触发纳米聚合,最大限度地减少持续药物递送的初始爆发释放.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 控制的类药物递送仍然是一个挑战,特别是实现长期释放,初始爆发最小.
- 专纳米颗粒为药物封装提供了一个生物相容的平台.
研究的目的:
- 通过使用离子触发的纳米聚合来研究长期受控释放带有的白纳米颗粒.
- 为了最大限度地减少最初的爆发释放,并调节药物释放率.
主要方法:
- 制备人血清白蛋白 (HSA) -油酸合物 (AOC) 具有不同的油酸 (OA) 替代比率.
- 在HSA-OA纳米颗粒 (PAS-AONs) 中封装发达酸 (PAS).
- 评估纳米粒子特性,负载和体外释放特征,包括离子触发聚合.
主要成果:
- 增加的OA替代减少了关键菌度,并提高了由于疏水相互作用的PAS负载效率.
- 较高的AOC疏水性延迟了释放速度,并将最初的爆发释放降到最低.
- 离子诱导了PAS-AONs的纳米聚合,在一个月内以度依赖的方式进一步降低了释放率.
结论:
- 调节OA替代和离子度在白蛋白-油酸纳米颗粒 (AONs) 允许可调节的,长期的药物输送.
- 这种方法有效地减少了最初的爆发释放,为持续的治疗效果提供了潜力.
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