病原体与宿主相互作用与垂直传播的共同进化可以产生可见的结果
Samantha Brotman1, Geoff Wild1
1Department of Mathematics, Western University, 1151 Richmond Street, London, Ontario, Canada.
Journal of theoretical biology
|February 26, 2025
概括
垂直传播可以导致不那么致命的病原体,但宿主恢复特征也在演变. 良性宿主-病原体相互作用的可能性更高,宿主人口增长和恢复成本增加,有利于较不严重的结果.
科学领域:
- 进化生物学 进化生物学
- 病原体动力学 病原体动力学
- 疾病生态学 疾病生态学
背景情况:
- 垂直传播通常预测可以减少病原体的毒性.
- 以前的模型假设病原体诱导的死亡率仅仅限制了宿主群体的增长,可能会忽视良性结果.
- 宿主群体调节影响宿主和病原体之间的共同进化动态.
研究的目的:
- 研究在自我调节的宿主人口增长下,病原体诱导的死亡率和宿主恢复的共同进化.
- 为了确定与垂直传播的宿主-病原体相互作用的稳定进化结果.
- 确定促进良性 (降级) 与严重 (升级) 主体-病原体关系的因素.
主要方法:
- 开发了一种跟踪病原体诱导死亡率和宿主恢复的数学模型.
- 假设自我调节的宿主群体增长,而不是仅仅由病原体引起的死亡率.
- 分析了不同垂直传播率下的死亡率和恢复特征的进化稳定策略.
主要成果:
- 确定了两个不同的稳定结果:"升级" (较高的死亡率/恢复) 和"降级" (较低的死亡率/恢复).
- 垂直传播的增加降低了稳定病原体的死亡率,但对宿主恢复有不同的影响.
- 较高的宿主人口增长,恢复成本和较低的水平传播有利于缓和,更温和的结果.
结论:
- 宿主种群的调节对于理解宿主-病原体共同进化至关重要.
- 当因素有利于"降级"稳定状态时,良性宿主-病原体相互作用的可能性更大.
- 降级结果的频率为共同进化良性提供了新的理解.
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