改变的单细胞亚群及其与儿童自闭症谱系障碍风险的关联
Wenhua Li1, Lingling Zhang2, Yiran Xu2
1Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg 40530, Sweden.
Brain, behavior, and immunity
|February 26, 2025
概括
高水平的古典和非古典单细胞,以及增加的IL-6产生,被确定为儿童自闭症谱系障碍 (ASD) 的潜在危险因素. 这些免疫变化也可能影响神经发育结果.
科学领域:
- 免疫学 免疫学 免疫学
- 神经发育障碍 神经发育障碍
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,越来越多的证据将免疫系统失调与其病理生理学联系起来.
- 了解免疫细胞 (如单细胞) 和它们在自闭症中产生的细胞因子的作用,对于识别潜在的生物标志物和治疗点至关重要.
研究的目的:
- 在患有自闭症的儿童中,研究单细胞亚群的变化及其细胞因子 (IL-6,IL-10) 的产生.
- 确定这些免疫变化与ASD风险和神经发育结果的关联.
主要方法:
- 来自患有ASD儿童的外周血液单核细胞和典型发育 (TD) 控制体的外周血液单核细胞使用流细胞计进行了分析,以评估单细胞亚群.
- 在体外刺激后,单细胞的细胞因子分泌 (IL-6,IL-10) 被测量.
主要成果:
- 与TD儿童相比,ASD儿童的总,经典和非经典单细胞水平显著更高.
- 较高的古典和非古典单细胞水平,以及单细胞增加的IL-6产生,与ASD风险有显著的关联.
- 较高水平的经典单细胞与自闭症儿童的适应性行为,精细运动和个人-社会发展系数负相关.
结论:
- 增加的古典和非古典单细胞种群代表了ASD的潜在风险因素.
- 这些免疫变化可能在影响ASD儿童的神经发育结果方面发挥作用.
- 需要进一步的研究来探索潜在的机制和针对ASD免疫失调的潜在治疗策略.
相关概念视频
01:19Autism Spectrum Disorder
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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01:30Attention-Deficit/Hyperactivity Disorder
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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
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