LGBTQ+身份及其与炎症和细胞免疫功能的关联
Ethan Morgan1, Claire M Kamp Dush2, Thomas W McDade3
1College of Nursing, The Ohio State University, Columbus, OH, USA; Infectious Disease Institute, The Ohio State University, Columbus, OH, USA.
Brain, behavior, and immunity
|February 26, 2025
概括
内化污名影响LGBTQ+免疫功能,增加炎症. 然而,身份肯定与性少数群体的炎症减少和更好的免疫健康有关.
科学领域:
- 免疫学 免疫学 免疫学
- 心理神经免疫学 心理神经免疫学
- 健康差异 在健康上的差异
背景情况:
- 在女同性恋,男同性恋,跨性别者,酷尔和其他性少数群体 (LGBTQ+) 中自我认同是复杂的.
- 很少有研究探讨了LGBTQ+身份对免疫参数的影响.
- 全国夫妇健康和时间研究 (NCHAT) 提供了一个具有全国代表性的数据集.
研究的目的:
- 检查LGBTQ+身份和免疫生物标志物之间的关系.
- 调查内部化耻辱和身份肯定如何影响免疫功能.
- 确定减少性少数群体健康差异的干预措施的潜在目标.
主要方法:
- 分析了NCHAT压力生物学研究 (NCHAT-BIO) 中289名LGBTQ+参与者的数据.
- 自我报告的人口统计,心理健康和LGBTQ+身份数据.
- 从干血斑点 (DBS) 中测定C反应蛋白 (CRP),IL-6 (IL-6) 和爱斯坦-巴尔病毒 (EBV) 抗体.
- 多变量回归分析调整为混因素.
主要成果:
- 在出生时被分配为女性的个体中,LGBTQ+自豪感与较低的EBV抗体水平相关.
- 在出生时被分配为男性的个体中,对隐私的渴望与CRP升高有关;希望异性恋与IL-6升高有关.
- 对LGBTQ+身份的骄傲预测了较低的IL-6水平.
- 与炎症升高相关的内化耻辱;与炎症降低相关的身份肯定.
结论:
- 在LGBTQ+个体中,内部化的耻辱与炎症增加和细胞免疫功能低下有关.
- 在LGBTQ+个体中,身份肯定与减少炎症有关.
- 调查结果强调需要采取干预措施来解决LGBTQ+健康差异.
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