患者治疗间歇性或轻度持久性喘时使用短效β2抗剂进行救援的恶化负担
Njira L Lugogo1, Ileen A Gilbert2, Hitesh N Gandhi3
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan.
概括
患有轻度喘的患者通常依赖短效β2-激动剂 (SABA) 并经历恶化. 转换为抗炎救援疗法可能会减少喘相关疾病.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 在美国,喘管理通常涉及对轻度疾病的治疗.
- 尽管有轻微的分类,但患者经历严重的喘恶化和死亡率.
- 目前的治疗模式可能无法充分预防轻度喘的不良结果.
研究的目的:
- 调查短效β2-激动剂 (SABA) 使用模式之间的关联.
- 为了检查SABA使用,喘恶化和药物坚持之间的关系.
- 在被诊断为间歇性或轻度持续性喘的患者中评估这些因素.
主要方法:
- 一项回顾性队列研究利用了来自Merative MarketScan (2010-2017) 的美国行政索赔数据.
- 12岁以上间歇性/轻度持续性喘患者的SABA索赔数据被分析.
- 在SABA填充组中比较了恶化和坚持 (药物持有率).
主要成果:
- 包括超过533,000名患者;70%的人有间歇性喘 (仅SABA).
- 高SABA使用量因治疗而有显著差异:仅使用SABA (14.8%),低剂量ICS (37.0%) 和LM (25.5%).
- 与低剂量ICS (40.4%) 或LM (50.4%) 用户相比,仅使用SABA的用户 (61.2%) 的恶化更频繁.
结论:
- 间歇性/轻度持续性喘患者经常使用SABA并经历恶化.
- 轻度持续性喘患者中很大一部分患者表现出不良的药物坚持 (<50%MPR).
- 从仅用SABA治疗过渡到抗炎救援疗法可能会降低喘相关的发病率.
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