在不同的葡萄糖代谢状态中,甘油三指数与缺血性中风风险之间的关联
Keyu Bian1, Chao Hou2, Huafeng Jin3
1Department of Neurology, Wujin TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, Jiangsu 213100, China; Department of Neurology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; Department of Neurology, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
甘油三糖 (TyG) 指数有效预测缺血性中风风险,特别是在正常葡萄糖或糖尿病前期患者中. 这些生物标志物有助于在不同葡萄糖代谢状态的早期检测和预防策略.
科学领域:
- 代谢健康 代谢健康
- 心血管流行病学心血管流行病学
- 生物标志物发现发现
背景情况:
- 胰岛素抵抗 (IR) 是缺血性中风的一个危险因素.
- 三甘油-葡萄糖 (TyG) 相关指数 (TyG,TyG-BMI,TyG-WC) 是IR的新兴生物标志物.
- 跨葡萄糖代谢状态的缺血性中风TyG指数的预测价值尚未得到充分研究.
研究的目的:
- 调查TyG相关指数与缺血性中风风险之间的关联.
- 评估TyG指数在正常葡萄糖,糖尿病前期和糖尿病组的预测效用.
主要方法:
- 利用了来自392,733名没有基线缺血性中风的参与者的英国生物库数据.
- 将参与者分为正常葡萄糖,糖尿病前期和糖尿病组.
- 采用了Cox的比例危险模型来分析TyG指数与中风发病率之间的关联,平均随访时间为14.68年.
主要成果:
- 在随访期间发生了8033次缺血性中风.
- 较高的TyG,TyG-BMI和TyG-WC与所有组中风风险增加有关.
- 在糖尿病前期和正常葡萄糖组中发现了最强的关联;TyG-BMI和TyG-WC在这些组中显示出显著的预测能力.
结论:
- 与TyG相关的指数,特别是TyG-BMI和TyG-WC,对于预测缺血性中风风险非常有价值.
- 这些指数在正常葡萄糖和糖尿病前期患者中特别有效.
- TyG指数为早期中风风险检测和预防策略提供了潜力.
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