用CES2A1作为产药肠道吸收模型的CES2A1携带修饰的Caco-2细胞的功能分析

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Updated: May 25, 2025

Using Caco-2 Cells to Study Lipid Transport by the Intestine
07:00

Using Caco-2 Cells to Study Lipid Transport by the Intestine

Published on: August 20, 2015

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Teruko Imai1,2, Masanari Isasaka1, Yusuke Oyama3

  • 1Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.

Biological & pharmaceutical bulletin
|February 26, 2025
PubMed
概括

一个新的Caco-2细胞模型 (CES2/Caco-2CES1KD) 准确地模仿肠道碳素化酶 (CES2A1) 活性,用于前药物代谢研究. 这种模型可以更好地评估吸收过程中的肠道药物水解.

关键词:
在Caco-2细胞中.通过N-乙化进行N-乙化.卡尔基酶 (Carboxylesterase) 是一种碳酸酶.肠道吸收 肠道吸收这是一种p-氨基子酸 Ester.药物前体是药物前体.

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