评估inclisiran在初级保健中的实施:过程评估 采访主要利益相关者的临时调查结果
Paul Wilson1, Rebecca Elvey2, Amy Mathieson2
1Centre for Primary Care and Health Services Research, University of Manchester, Manchester, UK paul.wilson@manchester.ac.uk.
BMJ open
|February 26, 2025
概括
新的胆固醇药物Inclisiran被认为可用于英格兰的初级保健实施. 患者和提供者支持其使用,尽管劳动力压力存在挑战.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 英克利西兰是一种新的,一流的小干扰RNA (siRNA) 疗法,向PCSK9降低LDL-C.
- 增加的低密度脂蛋白胆固醇 (LDL-C) 和动脉样硬化心血管疾病 (ASCVD) 仍然是严重的公共卫生问题.
- 初级保健机构为更广泛的患者获得先进的降脂疗法提供了潜在的途径.
研究的目的:
- 评估在英语初级保健中实施inclisiran和相关行为支持的可行性和可接受性.
- 收集患者,医疗保健提供者和研究人员关于inclisiran交付实用性的观点.
- 确定阻碍和促进inclisiran融入常规初级保健的障碍和促进者.
主要方法:
- 在VICTORION-Spirit研究中,采用混合设计,在IIIb期,多中心,随机对照试验中结合了过程评估.
- 通过对84名参与者进行半结构化访谈收集了定性数据,包括患者,全科医生,卫生顾问和研究护士.
- 使用定性快速分析方法来解释可实施性数据.
主要成果:
- 参与者普遍认为,施用inclisiran和提供行为支持的过程是直接的和有利的.
- 患者和医疗保健提供者表示,inclisiran可以有效地作为实践护士领导的服务提供.
- 确定的主要障碍包括初级保健工作人员和工作负载压力,并建议建立激励结构.
结论:
- 患者和医疗保健提供者表示支持在初级保健机构内实施inclisiran.
- 强调了患者的便利性和inclisiran作为现有治疗方法的补充的感知效用.
- 对一般实践资源和相关成本的担忧被认为是实施的重大障碍.
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