周围血液中的B细胞和T细胞种群与多发性硬化症治疗ocrelizumab疗效有关
Ece Akbayir1,2, Tugce Kizilay3, Ruziye Erol3
1Department of Neuroscience, Aziz Sancar Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkiye; ece.akbayir@atlas.edu.tr.
In vivo (Athens, Greece)
|February 26, 2025
概括
周围血液细胞子集可以预测在复发性缓解性多发性硬化症 (RRMS) 中的ocrelizumab治疗反应. 基线调控T细胞和B细胞的升高以及治疗后的具体变化表明治疗的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 奥克雷利祖马布是一种针对多发性硬化症 (MS) 的CD20单克隆抗体.
- 在复发性缓解性多发性硬化症 (RRMS) 中预测治疗反应对于优化患者的治疗结果至关重要.
- 了解外围血液细胞子集动态为治疗疗效提供了潜在的生物标志物.
研究的目的:
- 研究外周血液细胞子集在预测RRMS患者对ocrelizumab治疗反应中的有用性.
- 识别与治疗成功或失败相关的特定免疫细胞群.
主要方法:
- 31名对一线疗法耐药的RRMS患者被用ocrelizumab治疗了12个月.
- 使用扩展残疾状况尺度 (EDSS) 和MRI评估疾病活动.
- 外周血液单核细胞通过流动细胞测量免疫类型,以分析细胞子集.
主要成果:
- 奥克雷利祖马布治疗改变了B细胞和T细胞种群,减少了CD19+B细胞,增加了切换记忆B细胞和调节性T细胞.
- 19名患者没有证据表明疾病活性 (NEDA-3),他们表现出基线调控性CD49d+T和B-1a细胞的升高.
- 治疗后的天真T细胞增加和切换记忆B细胞减少与NEDA-3状态相关.
结论:
- 对ocrelizumab的治疗反应与基线调节性免疫细胞和治疗后的效应细胞群相关.
- 记忆B细胞被确定为在RRMS治疗ocrelizumab疗效的潜在生物标志物.
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