新发性双极性障碍在上腺炎患者中:一个多中心,倾向性得分匹配的队列研究
Meng-Che Wu1,2,3, Yun-Feng Li3, Chen-Yu Lin3
1Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
In vivo (Athens, Greece)
|February 26, 2025
概括
患有辅助性腺炎 (HS) 的患者面临患双相情感障碍的风险更高,尤其是女性. 这突显了医疗保健提供者管理HS患者的关键联系.
科学领域:
- 皮肤病学和精神病学
- 慢性病的流行病学 慢性病的流行病学
背景情况:
- 补腺炎 (HS) 是一种慢性炎症性皮肤疾病.
- 新出现的证据表明,HS与精神疾病 (包括双相情感障碍) 之间存在潜在联系.
研究的目的:
- 调查 hidradenitis suppurativa 和发展双相情感障碍的风险之间的联系.
- 与对照组相比,量化HS患者新发双相情感障碍的风险.
主要方法:
- 对60,850名HS患者和60,850名匹配对照者的电子健康记录进行分析.
- 利用倾向得分匹配和危险比率来评估双相情感障碍风险.
- 排除了先前存在双相情绪障碍诊断的个人.
主要成果:
- 患有HS的患者表现出显著增加患双相情感障碍的风险 (HR=1.549).
- 这种高风险在1,3年和5年的随访和敏感性分析中持续存在.
- 女性HS患者表现出明显更高的双相情感障碍风险 (HR=1.509).
结论:
- 患有辅助性腺炎的个体有显著增加患双相情感障碍的风险.
- 这种联系在女性患者中尤为明显.
- 临床医生在治疗HS患者时应考虑这种并发症.
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