韩国患者的SLE死亡率模式和相关风险因素:全国性队列研究
Soo-Kyung Cho1,2, Yena Jeon3, Jung-Hyo Kim4
1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seongdong-gu, Korea (the Republic of).
Lupus science & medicine
|February 26, 2025
概括
韩国系统性红斑狼 (SLE) 患者的死亡率高于与SLE相关的疾病,心血管疾病和癌症. 肺部并发症显著增加了与SLE相关的死亡风险.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 系统性红斑狼 (SLE) 是一种具有显著发病率和死亡率的慢性自身免疫性疾病.
- 了解死亡率模式和风险因素对于改善患者的治疗结果至关重要.
研究的目的:
- 调查韩国人口的死亡率模式,并确定与系统性红斑狼 (SLE) 相关的风险因素.
- 分析按性别和年龄分层的全因和因特定死亡率.
主要方法:
- 从2008年到2018年使用韩国国家健康保险数据库.
- 包括发生的SLE病例,年龄在10-79岁之间,分析每10万人/年的死亡率.
- 在风险因素分析中采用了概括估计方程模型.
主要成果:
- 分析了11,375例SLE病例;728例死亡发生在57,658人年内.
- 男性的死亡率比女性高.
- 死亡的主要原因包括与SLE相关的疾病,心血管疾病 (CVD),癌症和感染.
结论:
- 与SLE相关的疾病是韩国SLE患者的主要死亡原因.
- 心血管疾病和癌症也是死亡的重要原因.
- 肺部表现,包括肺膜出血和高血压,是SLE相关死亡的关键风险因素.
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