不同叶酸状况与美国成年人睡眠障碍的关联:来自NHANES 2007-2016年的数据
Jiayuan Tu1, Xiaoqiao Mo2, Zihao Chen3
1School of Nursing and School of Public Health, Yangzhou University, Yangzhou, China.
Sleep health
|February 26, 2025
概括
低和高的叶酸水平都与成人睡眠障碍的增加有关. 最佳的叶酸摄入量和血液水平可能会降低睡眠不良的风险.
科学领域:
- 营养科学 营养科学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 睡眠障碍是一个日益严重的公共卫生问题.
- 叶酸对各种身体功能至关重要,但其与睡眠的关系尚未完全理解.
研究的目的:
- 为了研究叶酸状况 (摄入量,血清和红细胞叶酸) 与美国成年人的睡眠障碍之间的联系.
- 为了确定睡眠健康的潜在最佳叶酸水平.
主要方法:
- 对20,200名成年人进行的横截面研究,使用了国家健康和营养检查调查 (NHANES) (2007-2016) 的五个周期的数据.
- 考克兰-阿米塔奇测试用于分析睡眠障碍随时间的趋势.
- 调查加权后勤回归,受限立方线模型和相互作用分析,以评估叶酸状况和睡眠障碍相关性.
主要成果:
- 在2007-2008年和2015-2016年期间,睡眠障碍的患病率从25.8%增加到29.3%.
- 低 (Q1) 和高 (Q4) 叶酸摄入量,以及高的红细胞叶酸 (Q4) 都与睡眠障碍的可能性增加有关.
- 观察到U形的非线性关联,每天摄入约439微克叶酸,血清叶酸35nmol/L和红细胞叶酸886nmol/L的风险最低.
结论:
- 在美国成年人中,叶酸状况和睡眠障碍之间存在U形关联.
- 不足够和过度的叶酸水平都可能对睡眠产生负面影响.
- 对睡眠健康的最佳叶酸范围进行进一步的研究是有必要的.
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