相关实验视频

Updated: May 25, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

7.5K

平衡行为:脂质与蛋白质的比率决定了α-synuclein的聚合命运

Christian Blum1, Mireille M A E Claessens1

  • 1Nanobiophysics, Faculty of Science and Technology, MESA+ Institute for Nanotechnology and Technical Medical Centre, University of Twente, the Netherlands.

Trends in biochemical sciences
|February 26, 2025
PubMed
概括

脂质与蛋白质的比率影响了α-synuclein (αSyn) 粉样蛋白的形成. 了解αSyn膜结合为疾病调节提供了新的策略.

关键词:
氨基化物 氨基化物脂质膜 脂质膜 脂质膜蛋白质聚合蛋白质的聚合物蛋白质膜相互作用囊中的囊泡.α-同核素 (αSyn) 是一种

更多相关视频

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast11:04

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast

Published on: June 23, 2018

7.2K
Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils00:15

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

5.9K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.2K