来自巴西迪奥米塞特 (Panus similis) 培养物的二度
Somporn Palasarn1, Prattana Tanyapanyachon2, Vanicha Vichai1
1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani 12120, Thailand.
Journal of natural products
|February 26, 2025
概括
这项研究从真菌Panus similis中分离出了新的染色体二聚体和染色体. 一种化合物2,2-二甲基-3,4,6-三氧克罗曼,对NCI-H187细胞具有选择性细胞毒性活性.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 药用化学 医学化学
背景情况:
- 帕努斯·西米利斯真菌产生二次代谢产物.
- 染色二聚体和染色体是具有潜在生物活性的自然产品类别.
- 以前的相关化合物的合成涉及到前古世II的二分化.
研究的目的:
- 从Panus similis中分离和描述新的化合物.
- 评估孤立化合物的细胞毒性和抗氧化活性.
- 确定单体的绝对配置.
主要方法:
- 从真菌培养提取物中分离化合物.
- 使用光谱方法阐明结构.
- 通过莫舍尔衍生物来确定绝对配置.
- 对NCI-H187细胞的细胞毒性测定.
- 使用DPPH测定进行抗氧化活性评估.
主要成果:
- 他们分离了四种染色体二极体 (panusimilins A-D) 和两种染色体.
- 2,2-二甲基-3,4,6-三基色胺表现出选择性细胞毒性 (IC50 9.1 μM).
- 泛西米林B显示出抗氧化活性 (IC50 66 μM).
结论:
- 帕努斯·西米利斯是新型染色体和染色体衍生物的来源.
- 孤立的化合物具有显著的细胞毒性和抗氧化特性.
- 对这些化合物的进一步研究可能会导致新的治疗剂.
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