老年男性的抵抗运动训练减少了骨肌肉中的ATF4激活和衰老相关的mRNA
Zachary D Von Ruff1, Matthew J Miller2,3, Tatiana Moro4
1University of Texas Medical Branch, Galveston, TX, USA.
GeroScience
|February 26, 2025
概括
抵抗运动训练在年轻和年长的男性之间不同地改变了骨肌肉中的基因表达. 老年人表现出更大的基因表达反应,训练后衰老相关基因减少.
科学领域:
- 分子生物学分子生物学
- 老年学是一门学科.
- 运动生理学 运动生理学
背景情况:
- 在老年人中常见的 Sarcopenia 增加了虚弱,疾病和死亡的风险.
- 抵抗运动训练可以增强肌肉功能和大小,但个体反应各不相同.
- 了解骨肌肉对运动反应的年龄相关差异至关重要.
研究的目的:
- 为了研究抵抗运动训练后骨肌肉转录组的年龄独立和年龄依赖的变化.
- 为了比较年轻和老年男性对抗力运动的分子反应.
主要方法:
- 从年轻和年长的男性中收集了骨肌肉活检,在12周的抵抗运动计划之前和之后.
- 用RNA测序来分析差异性的mRNA表达.
- 进行基因本体学和基因组丰富分析来解释数据.
主要成果:
- 抵抗运动训练在年轻 (226个mRNA) 和年长 (959个mRNA) 的男性中都诱导了差异性基因表达.
- 在年龄组之间的mRNA变化中观察到一个小的重叠 (94增加,17减少).
- 年长的男性表现出更大的差异性基因表达和ATF4激活和衰老相关的mRNAs的减少.
结论:
- 抵抗运动训练引起了骨肌肉中明显的年龄相关的转录基因变化.
- 在老年人中,训练减少了与衰老相关的基因表达.
- 训练后增加的肌肉质量和肌肉强度与与线粒体功能,转化和新陈代谢相关的特定基因表达模式相关.
相关概念视频
01:27Exercise and Muscle Performance
1.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.3K
01:26Aging
35
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
35