相关实验视频

Updated: May 25, 2025

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

用光子触发的热和铁双功能纳米平台用于癌症免疫疗法

Quansheng Cheng¹, Qingcheng Wang¹, Songnan Qu^2,3

¹Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078, China.

Light, science & applications

|February 26, 2025

概括

这项研究介绍了一种用于癌症治疗的双功能纳米平台. 该纳米平台针对癌细胞,并使用光子调解来诱导用于免疫治疗的热和铁.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

癌症免疫疗法仍然是一个挑战,需要新的治疗策略.
有针对性的药物输送系统对于提高治疗疗效和减少副作用至关重要.
诱导多个细胞死亡途径可以克服治疗耐药性.

研究的目的:

开发和描述用于癌症治疗的双功能纳米平台.
为了研究纳米平台在向癌细胞,pH反应和近红外光成像方面的能力.
评估纳米平台在诱导癌症免疫疗法中诱导火和铁的疗效.

主要方法:

合成和表征的双功能纳米平台.
在体外评估癌细胞向,pH响应和溶酶体向.
使用近红外光的光动力学疗法来触发热和铁.
癌细胞死亡诱导和免疫反应的评估.

主要成果:

该纳米平台展示了有效的癌细胞向和 lysosome 积累.
近红外光成像证实了纳米平台的分布.
光子调解成功诱导癌细胞同时发生热和铁.
观察到增强的癌症免疫疗法.

结论:

开发的双功能纳米平台显示了癌症免疫治疗的巨大潜力.
通过光子调解同时诱导热和铁是一个有前途的策略.
这种纳米平台为向癌症治疗和成像提供了一种新的方法.

更多相关视频

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

Published on: September 17, 2013

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.