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Updated: May 25, 2025

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
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Published on: March 3, 2016

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PBRM1将PBAF引导到周心体,并保护中心体的完整性

Karen A Lane1, Alison Harrod1, Lillian Wu1

  • 1Division of Cell and Molecular Biology, The Institute of Cancer Research; London, London, UK.

Nature communications
|February 26, 2025
PubMed
概括

该PBAF复合体,特别是其PBRM1子单元,保护中心分子结构和基因组稳定性. 丢失PBRM1会导致中间体的脆弱性,在癌症中呈现潜在的治疗脆弱性.

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