年龄,血压变化和估计的脉冲波速度之间的相关性
Marco A Vieira-da-Silva1,2, André B Bauab Filho3, Felipe Imanichi4
1Internal Medicine Department, Federal University of the Triangulo Mineiro, Uberaba, Brazil. marcovieiravs@gmail.com.
Scientific reports
|February 26, 2025
概括
年龄强烈影响脉冲波速度 (PWV) 比血压变化 (BPV) 的指标更大. 这项研究发现,PWV受到衰老的影响要大得多,而不是短期的心缩或心缩BPV.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 老年学是指老年学的学科.
背景情况:
- 以前的研究已经独立研究了衰老与血压变化 (BPV) 或脉冲波速度 (PWV) 之间的关系.
- 在同一个队列中,缺乏对年龄对BPV和PWV的影响的直接比较.
研究的目的:
- 调查和比较时间表年龄与短期BPV和PWV指标的关联.
- 为了确定哪个心血管参数,BPV或PWV,更受衰老的影响.
主要方法:
- 649名参与者的队列 (508人<60岁,141人≥60岁) 进行了测量.
- 血压变化 (BPV) 被评估使用门诊血压监测 (ABPM) 对缩 (SBPV) 和腹缩 (DBPV) 参数进行评估.
- 脉冲波速度 (PWV) 使用振荡计技术 (br-PWV) 测量,并通过公式估计.
主要成果:
- 在年龄和br-PWV (r=0.901,p<0.001) 之间观察到非常强的正相关性.
- 年龄和BPV指标之间的相关性较弱 (SBPV:r=0.492,p<0.001;DBPV:r=0.220,p<0.001).
- 与SBPV (R2=0.243) 和DBPV (R2=0.048) 相比,年龄解释了PWV变异的比例更高 (br-PWV的R2=0.812),特别是在老年人 (≥60岁) 中.
结论:
- 脉冲波速率 (PWV) 显著受到年龄的影响,而不是短期血压变化 (BPV).
- 根据PWV测量结果,年龄是影响动脉硬性的主要因素.
- 这些发现凸显了衰老对不同心血管参数的不同影响.
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