在异性造血细胞移植后,长期患者报告的结果
Sina Alexandra Beer1, Johanna Blättel2, Kristina Reuß2
1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany. sina.beer@med.uni-tuebingen.de.
Bone marrow transplantation
|February 26, 2025
概括
异质造血细胞移植 (alloHCT) 后的生命质量 (QoL) 长期改善,但疲劳和失眠仍然存在. 患者报告的结果 (PROM) 对于了解alloHCT幸存者的个人QOL恢复至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 全基性造血细胞移植 (alloHCT) 存活率正在改善,提高长期生活质量 (QoL) 的重要性.
- 当前的临床实践和研究往往忽视了alloHCT后的定期,长期的QoL监测,造成了知识差距.
- 患者报告结果测量 (PROM) 对于评估QoL至关重要,但在长期alloHCT随访中未得到充分利用.
研究的目的:
- 评估成年患者在异性造血细胞移植 (alloHCT) 后的长期生活质量 (QoL).
- 确定与长期aloHCT幸存者更好的QOL结果相关的因素.
- 强调使用患者报告结果测量 (PROMs) 进行全面的生存率评估的重要性.
主要方法:
- 对214名成年alloHCT接受者进行了横截面调查.
- 使用EORTC QLQ-C30和FACT-BMT PROM来评估生活质量 (QoL).
- 分析了数据,比较短期 (≤1年) 和长期 (>3年) 随访组.
主要成果:
- 长期alloHCT幸存者 (超过3年) 报告的QoL明显好于短期幸存者 (P=0.016).
- 长期幸存者报告了中等程度的疲劳和失眠.
- 与更好的QOL相关的因素包括男性性别,较低的ECOG绩效状态,RIC调节,没有复发,没有持续的免疫抑制,和全职就业.
结论:
- 虽然在 alloHCT 后,整体的 QoL 在长期内显著改善,但个别的恢复轨迹有所不同.
- 疲劳和失眠等持续症状突出了有针对性的支持性护理的领域.
- 强烈建议定期使用PROM,以更好地了解和管理alloHCT后的长期存活率.
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