风险因素和预测建模在美国人口与肉症:一个倾向性得分队列研究研究
Yao Sun1, Shuguang Yang1, Zengli Xiao1
1Department of Critical Care Medicine, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, P. R. China.
Scientific reports
|February 26, 2025
概括
血红蛋白 (Hb),乳酸脱酶 (LDH) 和全身免疫炎症指数 (SII) 的高水平与美国成年人中肉类风险增加有关. 这些生物标志物可能有助于早期发现和干预与年龄相关的肌肉损失的策略.
科学领域:
- 老年学是一门学科.
- 生物标志物 生物标志物
- 肌肉生理学 肌肉生理学
背景情况:
- 肉,与年龄相关的肌肉质量和力量的损失,显著增加了老年人的发病率和死亡率.
- 识别可靠的生物标志物对萨尔科佩尼亚的早期检测和有效的干预至关重要.
- 炎症越来越被认为是萨科佩尼亚病变的关键因素.
研究的目的:
- 调查特定生物标志物血红蛋白 (Hb),乳酸脱酶 (LDH) 和系统性免疫炎症指数 (SII) 之间的关联,以及美国大量人口中的麻症.
- 为了确定这些生物标志物水平的升高是否与肉类的风险增加相关.
- 评估这些生物标志物对肉症的预测价值.
主要方法:
- 从2003年到2018年,美国国家健康和营养检查调查 (NHANES) 的5615名参与者的数据分析.
- 参与者根据他们的Hb,SII和LDH水平被分为四分之一.
- 使用后勤回归模型来评估生物标志物水平和肉症风险之间的关系,控制潜在的混因素.
主要成果:
- 高水平的Hb,LDH和SII与较高的肉类的风险显著相关.
- 每个生物标志物的最高四分位数显示与最低四分位数相比,风险明显增加.
- 这些指标的综合预测能力 (曲线下的面积 - AUC) 为0.925,具有高灵敏度 (0.925) 和特异性 (0.743).
结论:
- 升高的Hb,LDH和SII是美国人口中与肉症相关的显著生物标志物.
- 这些发现强调了炎症在萨尔科佩尼亚发展中的关键作用.
- 这项研究表明,这些生物标志物有可能用于早期发现肉症并指导治疗干预.
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