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Updated: May 25, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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通过小分子化合物对Otop1通道进行偏好的全调制

Xiangjin Kong1,2, Jie Sun1,2, Hanhan Zhang3

  • 1The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.

Communications biology
|February 26, 2025
PubMed
概括

研究人员确定了三种增强Otop1质子通道活性的小分子,特别是在弱酸性条件下. 这些调制器为研究Otop1关门机制及其在味觉感知中的作用提供了新的工具.

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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

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