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Updated: May 25, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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局部结构灵活性驱动了计算设计的蛋白质组件中的寡态性

Alena Khmelinskaia1,2,3,4,5, Neville P Bethel6,7, Farzad Fatehi8,9

  • 1Department of Biochemistry, University of Washington, Seattle, WA, USA. akhmelin@cup.lmu.de.

Nature structural & molecular biology
|February 26, 2025
PubMed
概括

计算式蛋白质设计现在可以通过结合子单元灵活性来创建动态蛋白质组件. 这种方法允许多样化的结构,扩大了新型蛋白质功能和蛋白质工程中的应用的可能性.

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