表达式改变了OSA急性缺血性中风患者的内皮和纤维溶解生物标志物
Zhencan Huang1, Yanan Zhang1, Qingqing Sun1
1Sleep Centre, Department of Neurology, The First Hospital of Jilin University, Changchun, People's Republic of China.
BMC neurology
|February 26, 2025
概括
在急性缺血性中风 (AIS) 和阻塞性睡眠呼吸暂停综合征 (OSA) 患者中,血清纤维素,E-选择素和组织类型的等离子激素激活剂 (t-PA) 升高. 这些标记与OSA严重程度相关,有助于诊断.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 心血管研究研究心血管研究
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSA) 越来越多地被认为是急性缺血性中风 (AIS) 的并发症.
- 了解OSA和AIS之间的病理生理联系对于有效管理至关重要.
研究的目的:
- 在AIS患者中研究纤维素素,E-选择素和组织类型等离子体激活剂 (t-PA) 的血清表达水平,OSA的严重程度各不相同.
- 评估这些生物标志物在OSA存在时对AIS的诊断实用性.
主要方法:
- 分析了80名AIS患者的血清样本.
- 患者被分为非暴露,轻度和中度至重度OSA组,根据多睡眠图 (PSG) 和呼吸暂停-呼吸暂停指数 (AHI).
- 与酶相关的免疫吸收试验 (ELISA) 用于量化纤维素素,E-选择素和t-PA水平.
主要成果:
- 患有OSA的AIS患者表现出显著更高的兴奋和氧气脱度指数 (P < 0.001).
- 与未暴露组相比,中度至重度OSA组的血清纤维素,E-选择素和t-PA水平明显升高 (P < 0.001).
- 在这些生物标志物和OSA严重程度之间观察到正相关性. 在ROC分析中,纤维素的敏感度为84.4%,E-selectin的敏感度为80%,t-PA的敏感度为82.2%.
结论:
- 纤维素素,E-选择素和t-PA的血清水平升高是患有OSA的AIS患者的特征.
- 这些生物标志物与OSA的严重程度有显著的相关性.
- 这些发现表明,这些标志物在诊断与OSA同时发生的AIS方面具有潜在价值.
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