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在瑞典使用病毒转基因组学检测和遗传特征马类病毒

Anne-Lie Blomström¹, Annika Källse², Miia Riihimäki^3,2

¹Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. anne-lie.blomstrom@slu.se.

BMC veterinary research

|February 26, 2025

概括

这项研究使用病毒转基因组学来识别瑞典马的病毒,发现马类疹病毒,Torque teno equus virus 1等. 这些发现有助于开发更好的诊断马匹病毒感染.

科学领域:

兽医病毒学兽医病毒学
马的健康马的健康
分子流行病学分子流行病学

背景情况:

病毒感染显著影响马群福利和全球马业,许多疑似感染仍未被诊断出来.
识别和描述循环的马类病毒的需要对于疾病管理和预防至关重要.
这项研究的重点是瑞典马的病毒转基因组学,包括那些有发烧和对照组的马.

研究的目的:

通过病毒转基因组学,识别和描述来自瑞典马的血清和鼻样本中的病毒.
调查影响瑞典马群的病毒病原体的多样性.
为改进诊断试验和流行研究提供基础.

主要方法:

来自马的血清和鼻样本的病毒基因组分析.
检测到的病毒基因组的遗传特征.
选择病毒的定量PCR (qPCR) 查.

主要成果:

马类疹病毒 (EHV-2,EHV-5,EHV-4),Torque teno equus病毒1 (TTeqV1) 和马类复制病毒 (eqCopV) 在鼻子抽样中被发现.
在血清样本中检测到TTeqV1,马类复制病毒,马类循环病毒和马类病毒.
遗传特征显示了与美国和中国发现的病毒的高序列相似性;qPCR显示了较低的个体马匹检测率 (1.6%-9.4%).

结论:

在瑞典马群中发现了几种病毒,其中一些在瑞典或欧洲以前未被检测到.
几种病毒的完整或接近完整的基因组被遗传特征,提供了有价值的数据.
这些发现支持开发增强的检测方法和更大的流行研究,以改善马的福利.

关键词:

发烧发烧发烧马匹马匹马匹病毒转基因组学病毒转基因组学

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