系统性炎症反应指数作为所有原因和心血管死亡的风险因素,在患有呼吸道皮症的个体中使用
Ying Liu1, Xuejun Yin2, Yutong Guo3
1Department of Emergency, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.
BMC pulmonary medicine
|February 26, 2025
概括
像SIRI,NLR和NMLR这样的炎症生物标志物可以预测呼吸道肉症的死亡率. SIRI是最强的预测因素,有助于针对性干预措施的风险分层.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 呼吸道肉症与患者的不良结果有关.
- 有限的生物标志物存在于呼吸道肉症的风险分层.
研究的目的:
- 调查全血细胞计 (CBC) 衍生的炎症生物标志物与呼吸道肉类的死亡率之间的关联.
- 评估中性粒细胞对淋巴细胞的比率 (NLR),中性粒细胞对淋巴细胞的比率 (NMLR) 和全身炎症反应指数 (SIRI) 作为所有原因和心血管死亡率的预测指标.
主要方法:
- 来自NHANES (2007-2012) 的1673名可能患有呼吸道肉症的成年人的队列分析 (通过PEFR评估).
- 在2019年12月31日之前对死亡率进行后续调查.
- 多变量考克斯回归模型分析了NLR,NMLR,SIRI和其他CBC生物标志物 (PLR,dNLR,MLR,SII) 的死亡风险,调整为共变量.
- 调解分析评估了白蛋白的作用.
主要成果:
- 在平均116个月的随访期间,263人死亡 (68人死于心血管疾病).
- 较高的NLR,NMLR和SIRI与增加的全因和心血管死亡风险显著相关.
- SIRI是最强的预测因子 (aHR为所有原因的1.65,心血管死亡率为3.18).
- 专素部分调解了SIRI-死亡率关系 (12.1%).
结论:
- 升高的NLR,NMLR和SIRI与呼吸道肉症的死亡率更高有关.
- SIRI显示出对死亡率的最高预测能力.
- 将SIRI纳入临床实践可能会改善针对性干预的高风险患者的识别.
相关概念视频
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
41
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
41
COPD: Pathogenesis and Clinical Features
223
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
223
Psychoneuroimmunology: Cardiovascular Disease
24
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
24
Stress Response System
53
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
53
Inflammatory Response
1.7K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.7K


