在肥胖症中,慢性干扰增强了来自内脏脂肪组织的炎症性细胞因子释放
Lorenza Zinna1, Ludovica Verde2,3,4, Michele Francesco Di Tolla1
1Department of Translational Medicine, University Federico II, Naples, Italy.
Journal of translational medicine
|February 26, 2025
概括
肥胖的晚间类型表现出内脂肪组织炎症增加和改变的时钟基因表达,可能会增加代谢风险. 这突显了昼夜节律与炎症疾病之间的联系.
科学领域:
- 循环节生物学 日间生物
- 代谢健康 代谢健康
- 免疫学 免疫学 免疫学
背景情况:
- 循环节律障碍与肥胖和炎症性疾病有关.
- 个别的时间类型 (早晨,中午,晚上) 影响代谢健康.
- 晚上时代型通常表现为身体成分较差,代谢风险较高.
研究的目的:
- 为了研究不同时间型的肥胖患者内脏脂肪组织 (VAT) 的炎症概况.
- 检查与时间型有关的VAT中时钟基因的表达.
主要方法:
- 25名患有肥胖症的参与者被分为早晨,中期或晚上的时间类型,使用早晨-傍晚问卷 (MEQ).
- 使用多重ELISA分析了增值税活检的炎症标志物 (细胞因子,化学因子,生长因子).
- 在VAT中的时钟基因表达 (PER1,CLOCK,BMAL1) 用qPCR进行了评估.
主要成果:
- 与其他组相比,晚间时代型表现出较高的甘油三水平和较低的相角.
- 在晚间的时间类型中,VAT表现出明显增加的炎症标志物,包括IL-1β,IL-8,bFGF,MCP-1和MIP-1β.
- 晚间时代型中PER1 mRNA表达的增加与较高的VAT bFGF和IL-1β水平相关.
结论:
- 晚间类型的个体表现出增高的VAT炎症和改变的时钟基因表达,尽管整体代谢概况相似.
- 这些发现表明,时间型可能会通过炎症途径加剧肥胖的代谢风险.
- 针对昼夜节律和炎症可能是管理与肥胖相关的代谢并发症的策略.
相关概念视频
01:24Obesity
361
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
361
01:29Cholesterol: Significance and Regulation
496
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
496
01:24Chronic Pancreatitis I: Introduction
61
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
61
01:02Hypodermis
3.9K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
3.9K
01:27Psychoneuroimmunology: Cardiovascular Disease
24
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
24
01:24Overview of Lipid Metabolism
930
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
930