肠道衰竭作为危急疾病的原因和后果的审查
Danielle E Soranno1, Craig M Coopersmith2, Jessica F Brinkworth3
1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Critical care (London, England)
|February 26, 2025
概括
危急疾病严重扰乱肠道功能,导致失生症和透性增加. 这种胃肠道功能障碍导致多器官衰竭,强调需要更好的监测和治疗方法.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 危急疾病对胃肠道功能有深远的影响,包括微生物群体结构 (失生症),肠道透性,上皮细胞完整性和免疫反应.
- 肠道功能受损对多器官功能障碍综合征 (MODS) 的发展和延续作出了重大贡献.
- 目前评估危急病患者肠道功能的方法有限,治疗干预已显示出不一致的益处.
研究的目的:
- 审查当前对危急疾病中胃肠道功能障碍的理解.
- 识别知识差距并指导未来的研究方向.
- 总结第十届手术期间质量倡议 (POQI) 会议关于关键疾病中的肠道的研究结果.
主要方法:
- 文献综述和专家共识来自第十届POQI会议.
- 对关键疾病中的肠道病理生理学现有证据的综合.
- 确定未来研究和临床实践的关键领域.
主要成果:
- 危急疾病会导致广泛的肠道功能障碍:失调,增加肠道透性,上皮屏障缺陷,改变肠道免疫力和减少沟血流.
- 这些胃肠道干扰是MODS病变的核心原因.
- 在这种患者群体中,缺乏可靠的肠道功能测量方法和经过验证的治疗方法.
结论:
- 肠道在严重疾病和MODS的发展中发挥着关键作用.
- 迫切需要进一步的研究,以开发可靠的诊断工具和有效的治疗策略,以治疗严重病患者的胃肠功能障碍.
- 解决肠道完整性和功能对于改善重症监护的结果至关重要.
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