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Updated: May 25, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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在乳腺癌中,由阿斯巴拉内酶通过ATR通路调节驱动的放射治疗耐药性

Macarena Morillo-Huesca1, Ignacio G López-Cepero1, Ryan Conesa-Bakkali1,2

  • 1Centro Andaluz de Biología Molecular y Medicina Regenerativa - CABIMER, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla, Universidad Pablo de Olavide, Américo Vespucio 24, Seville, 41092, Spain.

Journal of experimental & clinical cancer research : CR
|February 26, 2025
PubMed
概括

阿斯巴拉金内酶 (AEP) 通过保持基因组稳定性和放射治疗耐药性来促进癌细胞的生存. 抑制AEP可能使瘤对化疗敏感,并作为治疗选择的预测生物标志物.

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