一个随机对照试验比较氨酸和氨酸作为性别确认的激素疗法在变性男性
Sankar Sinju1, Subbiah Sridhar1, Palaniyappan Sreenivasan1
1Department of Endocrinology, Madurai Medical College & Govt Rajaji Hospital, Madurai, Tamil Nadu, India.
Clinical endocrinology
|February 27, 2025
概括
乙酸 (TE) 和无酸 (TU) 两者都有效地支持跨性别男性的男性化. 由于注射频率较低,人们更喜欢非酸 (TU),因为这两种配方在性别肯定激素治疗中都显示出安全性和有效性.
科学领域:
- 内分泌学 在内分泌学.
- 跨性别者健康 跨性别者健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 是女性对男性 (FtM) 个体的唯一性别肯定激素治疗 (GAHT),旨在减少性别失调并诱导男性化.
- 了解不同激素配方的比较效果对于优化治疗结果至关重要.
研究的目的:
- 研究两种的临床,生化和荷尔蒙效应:乙酸 (TE) 和无酸 (TU).
- 为了比较TE的疗效和安全性与TU作为跨性别男性的GAHT.
主要方法:
- 一个未来的随机对照试验超过28个月,涉及58名丸素天真的跨性别男性.
- 参与者被随机分配,接受TE (n=29) 或TU (n=29).
- 临床 (例如,月经停止,头发生长,声音深化) 和生化参数 (血液学,脂质,激素概况) 在基线,6个月和1年的评估.
主要成果:
- 两组TE和TU都在一年内实现了所需的男性化效果.
- 在两组中都观察到血红蛋白,血红素,LDL胆固醇和水平的统计显著增加.
- 观察到HDL胆固醇和雌醇水平显著下降,尽管TU注射较少,但TE和TU组之间没有显著差异.
结论:
- 乙酸 (TE) 和无酸 (TU) 都是跨性别男性的安全,有效和耐受良好的GAHT选择.
- 两种配方之间在临床,生化或荷尔蒙参数方面没有发现显著差异.
- 由于其不太频繁的剂量间隔,提升了患者的坚持和方便性,因此更喜欢非酸 (TU).
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