食道癌和肠道微生物群的因果作用:双向孟德尔随机化研究
1Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Journal of evidence-based integrative medicine
|February 27, 2025
概括
这项研究发现肠道细菌和食道癌 (EC) 之间存在双向因果关系. 某些肠道微生物可能会影响EC风险,突出显示它们在预防方面的潜在作用.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 肠道微生物群的组成与食道癌 (EC) 发病率和预后有关.
- 肠道微生物群和EC之间的特定遗传关联仍然不清楚.
研究的目的:
- 调查肠道微生物群和食道癌 (EC) 之间的双向因果关系.
- 评估肠道微生物特征对EC风险的遗传影响,反之亦然.
主要方法:
- 使用双向门德尔随机化 (MR) 分析.
- 使用全基因组关联研究 (GWAS) 对肠道微生物组 (n=18,340) 和EC (n=740例,372,016例对照) 的数据.
- 进行了严格的SNP查和敏感性分析 (IVW,MR-Egger,加权中位数等). 确保结果的有效性.
主要成果:
- 增加 *Coprobacter*, *Ruminococcus1*, *Senegalimassilia* 和 *Veillonella* 的丰度与更高的EC风险有关.
- 减少*Eubacterium oxidoreducens*,*Lachnospira*,*Romboutsia*和*Turicibacter*的丰度与较低的EC风险有关.
- 对EC的遗传责任与肠道微生物群的变化有因果关系,包括*Eggerthella*,*Coprococcus 2*,*Christensenellaceae R.7*和*Intestinimonas*.
结论:
- 建立了肠道微生物群和食道癌症之间的双向因果关系.
- 表明肠道微生物群调节在EC的预防和管理中可能发挥作用.
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